Science Discovery

Blood group genotyping

Since genes encoding blood group antigens began to be identified in 1989, molecular techniques have been used to detect genetic variants responsible for antigens expressed on the surface of red blood cells. These antigens form the (molecular) basis of blood types. Genotyping has greatly reduced the cost of extended blood typing beyond ABO and RhD, such as C, E, and K, and has increased the wide adoption of extended antigen matching in transfusion medicine. Clinical testing for red cell antigens in patient care follows published minimum quality and operational requirements. Molecular analysis can identify gene ...